Wednesday 16 April 2025
15:00 BST / 16:00 CET / 10.00 EST
ICON is taking part in a Bioanalysis Zone panel discussion to discuss key developments within the field of ADC bioanalytics.
During this session several industry experts will explore the key trends relating to ADCs, including the techniques currently in use, the PK/ADA assays most commonly used, and the bioanalytical challenges associated with ADCs.
Discussion points will include:
- The techniques currently being used to assess ADCs vs just the antibody element
- The PK and ADA assays being requested by sponsors and their benefits
- The challenges associated with ADC bioanalysis and methods for overcoming them
- How ADC bioanalysis is predicted to evolve in the next 5 years
This panel will be guided by recent survey data collected by Bioanalysis Zone as part of their ADC spotlight. The panel will supplement these findings with their own opinions and answer questions via a live Q&A session.
Panelists:
Ashley Brant
Ashley is a seasoned leader in the bioanalytical industry with over 25 years of experience in driving process improvements that enhance productivity and ensure regulatory compliance across both large and small molecule bioanalytical streams.
Ashley’s career began after earning her biochemistry degree from Eastern Michigan University, performing EGFR receptor research with Elizabeth Butch. She then joined Parke-Davis/Warner Lambert. There, she assessed molecular biological interactions to evaluate the mechanisms of action and safety risks for early drug candidates. This role led her into the biomarker quantitation field and to mastering LC-MS/MS, integrating it with traditional ligand-binding assay methods. At Pfizer, Ashley expanded her expertise in regulated bioanalysis, developing methods specializing in ligand binding, antibody capture, endogenous molecules, and hybrid platforms, all while adapting to the evolving fast throughput demands of drug development.
Over the past 15 years, Ashley has led bioanalytical teams within contract research organizations, overseeing diverse areas such as mass spectrometry, ligand-binding assays, cell-based assays, flow cytometry, immunogenicity, and more.
Rachel Foreman
Rachel is a Senior Scientist in the Discovery Bioanalysis Group at AstraZeneca, specializing in targeted LC-MS/MS assays for early drug compounds and biomarker measurement. She works in collaboration with numerous teams to support the growing in vitro platform for safety assessments of novel oncology treatments. Before this role, Rachel completed her PhD in Clinical Biochemistry at the University of Cambridge (UK), where she developed bioanalytical methods to identify and quantitate novel peptide biomarkers for metabolism. It was during this research that Rachel learnt the importance of optimizing methods to improve assay detection limits and the potential benefits of using in vitro models for understanding diseases and therapeutic treatment.
Violet Lee
Dr M. Violet Lee is a Senior Principal Scientist at Genentech, specializing in bioanlaytical chemistry with expertise in protein/ large molecule, small molecule and post translational modification characterization, quantitation and immunogenicity risk assessment. Violet obtained her M.S in Chemistry from the University of Illinois at Urbana-Champaign (IL, USA) and went on to obtain her PhD in Chemistry from the University of Wisconsin-Madison (WI, USA). In 2013, Violet joined the Bioanalytical Sciences Department in Genentech, supporting projects ranging from late-stage research through clinical development of antibody-drug conjugates (ADCs) and novel large molecule modalities in oncology and ophthalmology. Violet’s group develops and implements immunoaffinity mass spectrometry-based PK assays, characterizes ADC ADME and quantifies associated catabolites, as well as assesses potential immunogenicity of biotherapeutics through MHC-II Peptide Proteomics. Violet has served as a member of the organizing committee and Chair of the discovery bioanalysis session for applied pharmaceutical analysis, was a member of the AAPS (VI, USA) ADC Bioanalysis Committee sub-team, and chaired the ‘Therapeutic Proteins, Antibodies, and ADCs’ session at The American Society for Mass Spectrometry (NM, USA).
Charlie Britten